Development and Evaluation of Polyvinylpyrrolidone K90 and Poloxamer 407 Self-Assembled Nanomicelles: Enhanced Topical Ocular Delivery of Artemisinin

Age-related macular degeneration is a multifactorial disease affecting the posterior segment of eye and characterized by aberrant nascent blood vessels that leak fluid. It ends with vision loss. In present study, artemisinin which poorly water-soluble has potent anti-angiogenic anti-inflammatory properties was formulated into nanomicelles for its ocular application activity using CAM assay. Artemisinin-loaded were prepared varying concentrations PVP k90 poloxamer 407 at different ratios showed spherical shape particles in size range 41–51 nm. The transparency cloud point developed artemisinin-loaded found to be 99–94% 68–70 °C, respectively. vitro release from 96.0–99.0% within 8 h. trans-corneal permeation studies exhibited 1.717–2.169 µg through excised rabbit cornea 2 Drug-free did not exhibit noticeable DNA damage an acceptable level hemolytic potential. remarkable compared suspension. Hence, might have potential treatment AMD.